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The mean follow-up time for this sample of patients is of 5?years. All implants were clinically and radiologically monitored at each year follow-up and data regarding facial mucosa height (the distance between the gingival zenith and the incisal edge of the prosthetic restoration), buccal, mesial, distal and lingual/palatal probing depth and inter-proximal bone peak were collected. Buccal bone width (BBW) value was evaluated during surgery and was recorded after implant placement. Inter-proximal Natural Product Library bone resorption was investigated by the use of individualized intra-oral RX tray, such to have always the same projection and measurements were acquired after setting 1?:?1 the images using the implant measures as a reference. All data were then inserted in a statistical software and processed. Afterwards the results were compared to those provided by the literature (an in-depth research was made through the PubMed and Google Scholar databases). Results The predictability of good profile about soft tissues is achieved by a simplified implant prosthetic protocol and an adequate prothesis design, progressing from healing abutment to definitive crown. After 3?years, soft Aldosterone tissue around implant doesn't show recession in comparison to soft tissue around adjacent molar that suffered recession. Conclusion and clinical implications An implant placement in the right position accompanied by a proper emergence profile prosthetic restoration gives a long predictability and ideal Selleckchem GDC973 aesthetics of gingival line. Zenith level can be controlled with a proper emergence profile shaping. ""Objectives: The aim of this study was to analyse the influence of the microtopography and hydrophilicity of titanium (Ti) substrates on initial oral biofilm formation. Materials and methods: Nine bacterial species belonging to the normal oral microbiota, including: Aggregatibacter actinomycetemcomitans, Actinomyces israelii, Campylobacter rectus, Eikenella corrodens, Fusobacterium nucleatum, Parvimonas micra, Porphyromonas gingivalis, Prevotella intermedia, and Streptococcus sanguinis were tested on Ti surfaces: pretreatment (PT [Ra