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e., organotypic slices in culture) stimulates neuroinflammatory PLA2 isoform activation pathways that may differ from those of PLA2 families in brain of similarly exposed adult rats. Developmentally, rat brain levels of cPLA2 are unchanged between neonatal and adult ages (Yoshihara et?al., 1992), so further research on EtOH-induced signaling differences among PLA2 families is needed to understand the respective mechanisms. Integrating in vitro results with adult in vivo studies should permit elucidation of the PLA2 families and groups that are important in neuroinflammatory oxidative signaling mechanisms triggered by chronic binge EtOH abuse. MASP1 This research was supported by the National Institutes of Health National Institute of Alcohol Abuse and Alcoholism (grants U01 AA018279, T32 AA13527, R21 AA011543) and the Loyola University Potts Foundation. ""Contextual memory, or memory for source details, is an important aspect of episodic memory and has been implicated in alcohol-induced fragmentary blackouts (FBs). Little is known, however, about how neural functioning during contextual memory processes may differ between individuals AZD6738 with and without a history of FB. This study examined whether neural activation during a contextual memory task differed by history of FB and acute alcohol consumption. Twenty-four matched individuals with (FB+; n?=?12) and without (FB?; n?=?12) a history of FBs were recruited from a longitudinal study of alcohol use and behavioral risks and completed a laboratory beverage challenge followed by 2 functional magnetic resonance imaging (fMRI) sessions under no alcohol and alcohol (breath alcohol concentration?=?0.08%) conditions. Task performance and brain hemodynamic activity during a block design contextual memory PFI-2 cell line task were examined across 48 fMRI sessions. Groups demonstrated no differences in performance on the contextual memory task, yet exhibited different brain response patterns after alcohol intoxication. A significant FB group by beverage interaction emerged in bilateral dorsolateral prefrontal cortex and posterior parietal cortex with FB? individuals showing greater blood oxygenation level-dependent response after alcohol exposure (p?