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He was subsequently Ribonucleotide reductase treated with SAHA on a clinical trial but taken off study due gastrointestinal side effects. He subsequently underwent 7?+ 3 induction chemotherapy with infusional cytarabine and idarubicin. A mid-cycle bone marrow biopsy was ablated, and a subsequent biopsy following marrow recovery documented first complete remission. Post-remission therapy consisted of two cycles of high dose cytarabine. Relapse was documented 12?months from diagnosis, and treated with fludarabine, high dose cytarabine, idarubicin, and gemtuzumab ozogamicin without response. He expired from progressive disease 16?months from initial diagnosis. A 21-year-old Caucasian female, previously healthy, presented with fever, cough, and sore throat. A CBC demonstrated: WBC 8200 cells/mcl, hemoglobin 7.9 g/dl, platelets 52,000 cells/mcl, with 83% circulating blasts. A bone marrow biopsy demonstrated Cisplatin in vivo 95% cellularity, with 91% myeloblasts (MPX+, NSE?, CD13/33/117+, CD34/HLA-DR?), consistent with a diagnosis of AML M1. Cytogenetics showed a 46 XY karyotype; FISH studies for a PML/RAR fusion were negative. Initial therapy consisted of 7?+ 3?+ 3 induction with infusional cytarabine, daunorubicin, and etoposide. A mid-cycle bone marrow biopsy 9% blasts with Vorinostat supplier bone marrow biopsy was ablated, and a subsequent biopsy following count recovery documented first complete remission. Post-remission therapy consisted of three cycles of high dose cytarabine. Relapse was documented 11?months from diagnosis and treated with fludarabine, high dose cytarabine, idarubicin, and gemtuzumab with concurrent filgrastim, resulting in second complete remission. She underwent matched unrelated donor stem cell transplantation following single-dose total body irradiation/high dose cyclophosphamide conditioning.