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Published by Wiley Periodicals, Inc. J Orthop Res 31:1686�C1693, 2013 ""It is generally supposed that the pattern of fracture healing in trabecular metaphyseal bone differs from that of diaphyseal fractures. However, few experimental studies to date have been performed, even though clinically many fractures occur in metaphyseal bone. Particularly, the influence of biomechanical factors has not yet been investigated under standardized conditions. Our aim was to correlate UGT1A7 the interfragmentary strain (IFS) with the bone-healing outcome in a controlled metaphyseal fracture model in sheep. Twelve sheep received a partial osteotomy in the distal femoral condyle close to the trochlea. The determination of the IFS by in vivo X-ray analyses and a finite element model revealed that the deflection of the osteotomy gap by the patello-femoral force during walking provoked increasing strains of up to 40%. Bone healing was evaluated after 8 weeks by the assessment of the bone mineral density and by histomorphometry in regions of interest that displayed differing magnitudes of IFS. In areas with strains below 5% significantly less bone formation occurred compared to areas with higher strains (6�C20%). For strains larger than 20% fibrocartilage layers were observed. Low IFS (Crizotinib in vitro to intramembranous bone formation, whereas higher strains additionally provoked endochondral ossification or fibrocartilage formation. It is therefore proposed that metaphyseal bone healing follows similar biomechanical principles as diaphyseal healing. ? 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:425�C432, 2011 ""Documenting the effectiveness of an occupation-based family-centered therapy approach, when providing therapy for a young child with feeding problems, is needed in a culture such as Korea, which has a strong medical model of service. A case study was conducted involving a 16-month-old boy with feeding problems. An occupation-based family-centered therapy approach was carried out for 10?weeks. The results indicated that this approach addressed the physical components R428 mw of the child's feeding problems and also the parent-child bonding, which together improved the overall family dynamics. Although these results may stimulate clinicians to consider an alternative approach to a medical model, further research with a larger sample is needed to provide sufficient evidence for therapists to shift to a new service delivery model. Copyright ? 2013 John Wiley & Sons, Ltd. Eating is arguably one of the most significant everyday occupations in which a human being as an infant actively participates and continues to participate throughout his or her lifespan on a daily basis (Absolom and Roberts, 2011). It is also one of the most basic and critical daily occupations essential for survival. The occupation of eating is deeply rooted social and cultural meanings (Law, 2002; Schuberth et al.