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, and senior clinical fellowships at the Centers for Disease Control, Atlanta, and Leeds Teaching Hospitals Trust, Leeds. More recently, selleckchem Steven held senior R&D positions at Bristol Myers Squibb, ConvaTec, Advanced Medical Solutions Plc and held an honorary Professorship in the medical school at West Virginia University. In 2011, Steven joined Scapa Healthcare Plc as Vice President of Global Healthcare R&D and in 2012 was awarded the position of honorary professor at the University of Liverpool. He has written over 300 scientific publications and conference abstracts on biofilms, antimicrobials, wounds, and infection control and has authored and edited seven textbooks. Steven has provided over 100 presentations globally at conferences, universities, and hospitals. He is an editor of the Journal of Medical Microbiology and holds a number of honorary and advisory board roles.""Significance: Methods employed for preventing and eliminating biofilms are limited in their efficacy on mature biofilms. Despite this a number of antibiofilm formulations and technologies incorporating ethylenediaminetetraacetic acid (EDTA) have demonstrated efficacy on in vitro biofilms. The aim of this article is to critically review EDTA, in particular tetrasodium EDTA (tEDTA), as a potential antimicrobial and antibiofilm agent, in its own right, for use in skin and wound care. EDTA's synergism with other antimicrobials and surfactants will also be discussed. Recent Advances: The use of EDTA as a potentiating and sensitizing agent is not a new concept. However, currently the application of EDTA, specifically tEDTA as a stand-alone antimicrobial and antibiofilm agent, and its synergistic combination with other antimicrobials to make a ��multi-pronged�� approach to biofilm control is being explored. Critical Issues: As pathogenic biofilms in the wound increase infection risk, tEDTA could be considered as a potential ��stand-alone�� antimicrobial/antibiofilm agent or in combination with other antimicrobials, for use in both the prevention and treatment of biofilms found within abiotic (the wound dressing) and biotic (wound bed) environments. The ability of EDTA to chelate and potentiate the cell walls of bacteria and destabilize biofilms by sequestering calcium, magnesium, zinc, and iron makes it a suitable agent for use in the management of biofilms. Future Direction: tEDTA's excellent inherent antimicrobial and antibiofilm activity and proven synergistic and permeating ability results in a very beneficial agent, which could be used for the development of future antibiofilm technologies. Steven L.