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These abnormalities included skin manifestations such as a lack of the ��cupids bow�� and widening of the philtrum, clinodactyly of the fingers, and juvenile type glaucoma.14 Holan et al13 in 1991 reported single-rooted primary and permanent molars in two siblings. Manoj Kumar et al15 in 2010 reported multiple conical single-rooted permanent and primary teeth with oligodontia in a 11-year-old boy. Ganesh et al16 in 2012 reported a case of bilateral single-rooted primary molar (table 1). Table?1 Cases of single-rooted primary molars reported All the cases aforementioned either had genetic association or syndrome-related anomalies and at least more than one tooth involved. In this case, there was no syndrome related to the condition. Genetic correlation could not be confirmed and only one tooth has this type of anomaly. In short, to render the best endodontic service to the patients, the dentist must have a thorough knowledge of root canal anatomy and their variations. If knowledge of dental anatomy is insufficient then it may lead to some procedural defects during endodontic treatment and may cause an endodontic emergency to arise. So, this article reported a rare variation of unilateral single-rooted primary first molar and its endodontic treatment. Although there is no reported literature regarding any further complications of such teeth. No literature stated any kind of impaction, structural anomalies or delay in eruption of successors of such teeth. We are trying to determine the differential rate of resorption in single-rooted molars and other multirooted molars in the same case. This case report brings to light untrodden facts of dentistry. Learning points Knowledge of dental anatomy can facilitate more effective canal identification. To identify and recognise canal configuration is very important. Prevent unnecessary removal of healthy tooth structure in an attempt to search for missing canals. Footnotes Contributors: All authors have made substantive contribution to the manuscript, and all have reviewed the final version prior to its submission. Competing interests: None. Patient consent: Obtained. Provenance and peer review: Not commissioned; Selleckchem Vemurafenib externally peer reviewed.""Chronic pain is notoriously difficult to treat, is a major contributor to time away from the workplace each year and places a significant strain on the resources of the National Health Service. Once the conventional medications that are incorporated in the WHO pain ladder have been tried but there is still significant pain and disability, we often find it difficult to know where to go next. Case presentation We highlight the case of a 56-year-old man who was diagnosed with squamous cell carcinoma of the right side of his lower lip in 2008 with spread to his right submandibular gland. He underwent a local resection and neck dissection with adjuvant chemoradiotherapy.