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The amplitude of shortening was reduced in myocytes from the control�Csucrose group compared with control rats and in the GK�Csucrose group compared with GK rats. The amplitude of the Ca2+ transient was increased in myocytes from control�Csucrose compared with control rats and decreased in GK�Csucrose compared with GK rats. Subtle alterations in the pattern of expression of genes encoding a variety of cardiac muscle proteins are associated with changes in shortening and intracellular Aldosterone Ca2+ transport in ventricular myocytes from GK T2DM and control rats fed a sucrose-enriched diet. ""The chemokine, fractalkine, independently enhances the vulnerability of coronary atherosclerotic plaques. The present study investigated the combined effects of CD36 and fractalkine on coronary plaque progression in patients with unstable angina MLN8237 pectoris. In the present study, 120 unstable angina pectoris patients undergoing coronary angiography and intravascular ultrasound were divided into two groups: an intermediate lesion group (lumen diameter stenosis 50�C70%, 80 patients) and a severe lesion group (at least one lesion with lumen diameter stenosis >?70%, 40 patients). The control group consisted of 40 healthy age- and sex-matched subjects. Concentrations of CD36 and fractalkine were measured by enzyme-linked immunosorbent assay. Major adverse cardiovascular events were monitored over a 2-year follow up. Intravascular ultrasound showed that patients with severe lesions had more calcified and mixed plaques, and a larger plaque area and plaque burden than patients with intermediate lesions (P?C59 order than controls (P?