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Participants were tested for serum-specific immunoglobulin E (IgE) levels to food allergens as well as blood Selleck BLU9931 lead levels. Food allergens tested included shrimp, egg, peanut, and milk. Logistic regression models adjusted for demographic factors, body mass index, history of asthma, smoking, housing characteristics, and current exposure to animals in the home, to assess the association of blood lead levels with sensitization to food allergens. Median (interquartile range [IQR]) for serum blood was 0.87 ��g/L (0.61 to 1.31) in children and 1.48 ��g/L (0.92 to 2.34) in adults. At baseline, 672 (24.7%) of children participants and 719 (16.6%) of adult participants tested positive for increased sensitization to food allergens. A 2-fold increase in blood lead levels in adult participants was associated with increased sensitization to food allergens (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.02 to 1.22). Blood lead was not associated with sensitization to food allergens among pediatric participants (OR, 0.95; 95% CI, 0.82 to 1.10). Exposure to lead was associated with increased odds of sensitization to food allergens in adult but not children participants. ""The role of small airway obstruction in the Suplatast tosilate clinical expression of asthma is incompletely understood. We tested the hypotheses that markers of small airway obstruction are associated with (i) increased asthma severity, (ii) impaired asthma control and quality of life and (iii) frequent exacerbations. Seventy-four adults with asthma and 18 healthy control subjects underwent impulse oscillometry (IOS), multiple breath inert gas washout (MBW), body plethysmography, single-breath determination of carbon monoxide uptake and spirometry. Patients completed the six-point Asthma Control Questionnaire (ACQ-6) and standardized Asthma Quality of Life Questionnaire [AQLQ(S)]. Asthma severity was classified according to the Global Initiative for Asthma (GINA) treatment steps. The putative small airway obstruction markers Sacin, resistance at 5?Hz minus resistance at 20?Hz (R5-R20) and reactance area (AX) were not independently associated with asthma severity, ATR inhibitor control, quality of life or exacerbations. In contrast, markers of total (R5) and mean airway resistance of large and small airways (R20) were significantly higher in the severe asthma group compared with the mild�Cmoderate group (0.47 vs. 0.37, P?