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Understanding how they do this and how to incorporate this ability into future EWSs are important areas for future research. Acknowledgments DAC was supported by a Royal Academy of Engineering Research Fellowship, and by the Centre of Excellence in Personalised Healthcare funded by the Wellcome Trust and EPSRC under grant number WT 088877/Z/09/Z. MAFP was supported by the RCUK Digital Economy Programme under grant number EP/G036861/1 (Centre for Doctoral Training in Healthcare Innovation). The authors wish to thank the ward staff involved in this project. The authors also wish to thank the research nurses for the collection of clinical data used in this investigation and Marco Pimentel for his work on the database. Footnotes Contributors: DAC undertook data analysis and the initial drafting of the paper. Lei Clifton populated the databases and undertook initial data analysis. D-MS cleaned the databases and undertook the work underlying the errors in agreement between researchers�� analysis of the track and trigger charts. PJW ran the study, wrote the paper from the original draft, and developed the original ideas, as well as the analysis plan. GBS undertook an extensive external review of the proposed paper in collaboration with PJW, which made substantial improvements to the paper, including the inclusion of types of errors when interpreting the charts. SAV had the original idea for the paper, undertook data collection and data entry, and revised the paper. LT co-wrote the paper and contributed to the analysis plan. Funding: The work described in this paper was funded by the NIHR Biomedical Research Centre Programme (Oxford). Competing interests: PJW and LT have developed an electronic early warning score supported by the Engineering and Physical Sciences Research Council and the Oxford Biomedical Research Centre which is in local use within the Oxford University Hospitals NHS Trust. GBS is a co-designer of VitalPAC, an electronic vital signs and early warning system manufactured by The Learning Clinic (TLC). GBS's wife is a minority shareholder in TLC. GBS acts as an unpaid research adviser to TLC and has received reimbursement of travel expenses from them for attending symposia in the UK. GBS acted as expert advisor to the National Institute for Health and Clinical Excellence during the development of the NICE clinical guideline 50: ��Acutely ill patients in hospital: Recognition of and response to acute illness in adults in hospital��. He was also a member of the National Patient Safety Agency committee that wrote the two reports: ��Recognising and responding appropriately to early signs of deterioration in hospitalised patients�� and ��Safer care for the acutely ill patient: learning from serious incidents��. He was a member of the Royal College of Physicians of London's National Early Warning Score Development and Implementation Group (NEWSDIG). Ethics approval: Mid and South ABT-888 solubility dmso Buckinghamshire REC.