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e., buy Ixazomib interviews lasted no more than 60?minutes. These were transcribed verbatim by the interviewer and enabled the participants to confirm the validity of the transcription. All references to safety practice were noted. Qualitative analysis was made to understand the management of failures, and particularly ways of preventing and mitigating them effectively. When they watched the videos and were confronted with their behaviour and activities, team members detected all incidents. The surgeon, the two anaesthetists and the two nurses respectively verbalized seven, 13 and 10 incidents they were directly GSKJ4 involved in, while they verbalized six, eight and 12 incidents they were not directly involved in. Describing their behaviours and activities, all team members spontaneously and regularly referred to the institutional procedures in use in the OR at the time of the operation: 22 references were noted for the surgeon, 19 for the two anaesthetists, and 45 for the two nurses. The World Health Organization surgical safety checklist [14] was the most cited procedure, followed by the one related the prevention of surgical site infections. Procedures were evoked to prevent failures. For example, a nurse said: ��it is an institutional protocol, we catheterize all patients before operations of over two hours�� duration�� or ��all nurses are using two pairs of gloves, which is a recommendation from the Local Nosocomial Infections Surveillance Committee��. The anaesthesiologists also evoked procedures in the correction or mitigation of all but one of the incidents they were involved in. Commenting on incidents�� correction and mitigation, the surgeon, the anaesthetists, and the nurses, evoked variable contributions of knowledge, skills and attitudes, which are summarized in Fig. 3. Knowledge was the most quoted competence mobilized to manage incidents, followed by skills and attitudes. Nevertheless, the staff neurosurgeon, the resident anaesthetist, and the more experienced scrub nurse ranked skills first. Half of the references to attitudes came from one team member, the surgeon. S6 Kinase In this prospective video-based observational approach, the ways incidents were detected and then corrected or mitigated, emphasized two complementary aspects of clinical performance. The first aspect is associated with an individual practitioner, which corresponds to the non-interdependent components of an individual's performance and mainly includes practical knowledge and skill in performing specific procedures. The second aspect is then the interdependent aspects of performance, or the components of OR team members�� tasks that require joint action to be completed.