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The bronchodilator response (BDR) has also been shown to correlate with markers of airway inflammation, Selleck Lapatinib including eNO at 50?ml/sec (FENO,50) which is comprised of NO from both the proximal and distal airways. Using eNO at multiple flows and a two-compartment model of NO exchange, the eNO signal can be partitioned into its proximal [J'awNO (nl/sec)] and distal contributions [CANO (ppb)]. We hypothesized that the BDR reflects the inflammatory status of the larger airways with smooth muscle, and thus would correlate with J'awNO. In 179 predominantly (95%) Hispanic children with mild asthma (69 steroid na?ve), and 21 non-asthmatic non-atopic controls, spirometry and eNO at multiple flows were measured prior and 10?min following inhalation of albuterol. A trumpet-shaped axial diffusion model of NO exchange was used to characterize J'awNO and CANO. The BDR correlated moderately (r?=?0.44) with proximal airway NO (J'awNO), but weakly (r?=?0.26) with distal airway/alveolar NO (CANO), and only in inhaled corticosteroid na?ve asthmatics. A BDR cut point as low as ��8% had a positive predictive value of 83% for predicting an elevated J'awNO or LY294002 order FENO,50. We conclude that the BDR reflects inflammation in the large airways, and may be an effective clinical tool to predict elevated large airway inflammation. Pediatr Pulmonol. 2010; 45:174�C181. ? 2010 Wiley-Liss, Inc. ""Standard exhalation time for measuring fractional exhaled nitric oxide (FeNO) is 10?sec, but this is not easy for younger children. We aimed to investigate the agreement between FeNO values during 10-sec (FeNO-10) and 6-sec (FeNO-6) exhalation and the feasibility of measuring FeNO-6, using a hand-held analyzer, NIOX-MINO?. S6 Kinase FeNO values measured during 10- and 6-sec (random order) were compared. Success rates of the two different time modes were also evaluated. In 119 asthmatic children (median age 8 years [range 4�C15]) who had been already accustomed to NIOX-MINO?, median FeNO-10 (29?ppb [IQR 15.2�C42.0]) and FeNO-6 (27?ppb [IQR 16.0�C43.5]) did not differ significantly (P?=?0.90), and there was a good correlation between both values (r?=?0.984, P?