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In primary prevention strategy, statin use has remained a debatable topic in patients at relatively low risk and without the manifestation of CVD. However, a meta-analysis of a large statin trial reported over one-fourth relative reduction in risk of cardiovascular events in both primary and secondary prevention with statin, and also in patients with varying risk factor profiles [15]. The guidelines on cholesterol treatment recommends use of statin therapy in primary prevention based on CVD profile and low density lipoprotein (LDL)-C level of patients [17]. In addition, the guidelines recommend statin therapy only in patients with average or below average risk for diabetes mellitus (with LDL-C levels Tenofovir in vivo and two or more risk factors [14]. In 2009, Brugts et al. [16] reported a meta-analysis of 10 randomized clinical trials (RCT) that involved 16,078 and 23,681 men and women, respectively, with diabetes mellitus, and had a mean follow-up of 4.1?years. The findings of the meta-analysis showed that there was a considerable lowering of all cause mortality, major coronary and cerebrovascular events with the treatment of statin, and that the statin treatment did not increase the risk of cancer. No significant differences were observed with respect to the treatment effects in the study sub-populations. Hence, it was Oxymatrine concluded that in asymptomatic patients with cardiovascular risk factors, treatment with statin considerably increased survival rate, and showed greater reduction in the risk of major cardiovascular events [16]. However, in day-to-day clinical practices, statin therapy is reported as costly for primary prevention in individuals considered to be at low risk of vascular disease, despite the fact that generic statins are available at considerably low costs. It was suggested that the cost of statin therapy in Apoptosis inhibitor primary prevention could be reduced through strict adherence to statin therapy [18]. In 2011, Taylor et al. [19] reported a meta-analysis for primary prevention with statins. The study involved 14 randomized control trials conducted from 1994 to 2006. In this study, all randomized control trials compared statins with the dummy or usual care, and consisted of ?1?year treatment and a six-month follow-up period. The findings of the meta-analysis revealed a significant reduction in statin side effects, muscle pain, including cancer. The study also showed reduction in all-cause mortality and revascularization process with statin treatment in individuals without manifestations of CVD. Recently, Taylor et al. [20] reported another systematic review that included 18 RCTs with statins. The study compared statin treatment with a dummy or usual care control with ?1?year and a six-month follow-up period in adults without restrictions on total, LDL, or high density lipoprotein (HDL) cholesterol levels, and where 10% or less of study participants had a history of CVD.