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Multivariate Cox proportional hazards regression models were used to control for confounding variables [20]. Multivariate Cox regression models initially included age at operation, FIGO stage, tumor differentiation, pathological subtype, lymphatic metastasis, residual tumor size and the expression of Lewis y, CD44, CD147, HE4, and integrins ��5, ��1, ��v, ��3. Only those variables with P-value Venetoclax cost the univariate analysis were included in the multivariate analysis. Follow-up time was calculated from the date of surgery to the date of progression, death, and last visit or contact with the patient. Overall survival (OS) was defined as the time interval between the date of surgery and MMP23B the date of death; progression-free survival (PFS) was defined as the time interval between the date of surgery and the date of identification of progressive disease (disease not treatable with curative intent). For all three endpoints the last date of follow-up was used for censored subjects. Statistical analyses were performed using SPSS program (Version 22 for Mac; SPSS Inc., Chicago, IL, USA) and the Kaplan-Meier curve graphs were completed using Graph Pad Prism 5 (Graph Pad Prism Software Inc. San Diego, CA). A P-value Ibrutinib price sensitive to chemotherapy) and 36 patients were included in the resistant group. The age in these two groups were 52.70 �� 9.28 years�� old and 56.42 �� 9.48 years�� old, respectively. All the patients had undergone cytoreductive surgery of EOC. According to the 2010 International Federation of Obstetricians and Gynaecologists (FIGO) Staging System for Ovarian Cancer, there were 18 patients in stage I, 13 patients in stage II, 59 patients in stage III, 2 patients in stage IV. 35 cases were poor-differentiated, 43 were moderate-differentiated, and 14 were well-differentiated. By histological analyses [21], 60 patients were Serous carcinoma, 8 were mucinous carcinoma, 6 were endometrioid adenocarcinoma, 7 were clear cell carcinoma, 9 were poorly differentiated adenocarcinoma and 2 were undifferentiated. There were 29 patients who had lymph node metastasis, and 53 patients whose residual tumor size were no more than 1 cm and 22 patients 1-2 cm and 17 patients more than 2 cm. General clinical and pathological information of patients were shown in Table 1.