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The volumes of the thalamo-frontal projections showed a significant negative linear relationship with age bilaterally. There was no significant relationship between the volumes of the thalamo-cortical projections to the parietal, temporal, and occipital cortex and age (Fig.?3, Table?2). Volume loss with increasing crotamiton age in thalamo-frontal projections was significantly greater than volume loss in the thalamo-cortical projections to the parietal cortex (Left frontal versus left parietal, F?=?8.83, DOF?=?81, p?=?0.012. Right frontal versus right parietal, F?=?73.1, DOF?=?81, P?Selleckchem U0126 Selleck beta-catenin inhibitor significantly with increasing age (p?