The Very Atypical Oxacillin Adventure

After exclusion of term infants, 151 preterm infants with sepsis were included in the study. Groups 1, 2 and 3 consisted of 23, 86 and 42 infants, respectively. Table?1 lists the demographic features of the infants in three sepsis groups. EOS, Oxacillin LOS and VLOS were diagnosed in 15%, 57%, and 28% of infants, respectively. CONS was the most common organism, accounting for 77 cases (50.9%), followed by Candida spp. (15.8%). Table?2 lists the distribution of pathogens among the 151 cases. The main factors associated with EOS included low birthweight, presence of PROM, antibiotic use in pregnancy, maternal infection, and choriamnionitis. Previous antibiotic use (91%) was the main factor associated with LOS, whereas prematurity and low birthweight were other factors. Prematurity and low birthweight were also found to be main factors associated with VLOS. Table?3 lists the factors associated with EOS, and Table?4 presents a comparison of the factors associated with LOS and VLOS, which were different from EOS. Table?5 presents the clinical findings according to the three sepsis groups. The incidence of pneumonia was significantly higher in infants check details with VLOS compared with those with EOS and/or LOS. The infection-associated mortality was significantly higher in infants with LOS (19.7%) compared with those in group 1 (13%) and group 3 (4.7%). Table?6 lists the complications for the three sepsis types. Although CONS was the most common organism in all sepsis types, the mortality rate due to CONS was low in infants with EOS. The mortality rate due to CONS, however, was higher in infants with both LOS and VLOS. Gram-negative pathogens (35.2%) and fungi (35.2%) were the most common pathogens associated with mortality in LOS and they were followed by CONS (17.6%). CONS and Candida were again the predominant pathogens that led to mortality in VLOS. Mean leukocyte count LY2109761 was significantly higher in group 1 compared with groups 2 and 3 (P