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The lungs, skin and nervous system are the major organs that are affected by SM exposure in the late phase. Among these organs, pulmonary complications are the most common problem [1, 5]. A variety of different conditions can be seen in survivors [2, 6], including asthma, bronchiectasis, pulmonary fibrosis, chronic bronchiolitis and chronic obstructive RO4929097 pulmonary disease (COPD). The exact pathogenesis of the late pulmonary complications has not defined yet [5]. The previous studies have shown that maybe systemic inflammation and oxidative stress have role in late phase [2, 4]. Functional lung impairments in chemical warfare patients can adversely affect the physical, social and psychological health; these factors are known as the health-related quality of life [7, 8]. The mainstay of COPD treatment focuses on alleviating symptoms, preventing exacerbation and hospitalisation, and improving the health-related quality of life and exercise capacity [9, 10]. It is recommended that in addition to considering pulmonary function test results, the patient's health status, which is a combination of symptoms, the level of daily activity and the total impact of COPD on the patient's life, be evaluated and used for treatment guidance [11-13]. Different questionnaires are available to assess the health-related quality of life, including the Clinical COPD Questionnaire [14], the Chronic Respiratory Questionnaire [15] and the St. Georges Respiratory Questionnaire (SGRQ) [16]. These questionnaires are valid but complex [11]. Recently, a short Fleroxacin and simple health status questionnaire designed by Jones and colleagues, the COPD assessment test (CAT), was shown to correlate well with the SGRQ [11, 12]. CAT is valid and has valuable measurement properties [11]. The CAT score is associated with important clinical parameters and can be used in routine clinical practice to evaluate the health status during stable and exacerbated disease conditions [17, 18]. Scores are also sensitive to improvements in patient health following COPD exacerbations [19]. Additionally, the CAT questionnaire is a valuable tool for measuring outcomes of COPD patients [20]. This study was designed to evaluate the performance of the CAT questionnaire in chemical Luminespib molecular weight warfare patients diagnosed with COPD and the questionnaire's ability to identify the severity of disease. A total of 82 chemical warfare patients with all levels of COPD in stable condition were entered into this cross-sectional study from March 2010 to April 2011. All patients had validated documents demonstrating SM exposure and suffered from important late complications. According to the American Thoracic Society (ATS) definition [21], patients with a forced expiratory volume in 1?s (FEV1)/forced vital capacity (FVC)