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We would also like to acknowledge the support of the UK Stroke Association who funded much of the research detailed in this overview. ""Many patients would prefer not to be patients, particularly when their aneurysm is detected as a result of screening. Too much surveillance is the equivalent of over treatment. However, until recently there has been little evidence as to how often a patient with a small abdominal aortic aneurysm should have their aneurysm size monitored and, as a result, Carfilzomib research buy the frequency of surveillance varies in different screening programmes.1 Recently, the RESCAN Collaborators reported their findings based on individual patient data from more than 15,000 persons with small abdominal aortic aneurysm, from 18 surveillance studies across the globe.2 Typically, patients with aneurysm diameters in the range 3.0�C5.4?cm undergo surveillance, whereas those reaching 5.5?cm or above are considered for surgery. With individual U0126 mouse patient data, it is possible to restrict the information about growth and rupture to the surveillance range of 3.0�C5.4?cm diameter aneurysms, estimate the risk of rupture while under surveillance, and predict how long it will take for an aneurysm of known diameter to exceed the 5.5?cm threshold. For each 0.5?cm increase in aortic diameter, the RESCAN project found that the growth rate increased on average by about 0.6?mm per year and the rupture rate approximately doubled. The large majority of screen-detected aneurysms have diameters of Olopatadine aneurysm, was only 3.2 per 1000 patient-years. For these patients, with initial aneurysm diameter