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Taketomi A, Yamashita Y, Shirabe K, Hamatsu T, et al. Clinical significance of histone deacetylase 1 expression in patients with hepatocellular carcinoma. Oncology 72: 6974. 41. Hsu HC, Tseng HJ, Lai PL, Lee PH, Peng SY Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor development and invasiveness. MedChemExpress GW3965 (hydrochloride) Cancer Res 53: 46914694. 42. Vleugel MM, Shvarts D, van der Wall E, van Diest PJ p300 and p53 levels identify activation of HIF-1 downstream targets in invasive breast cancer. Hum Pathol 37: 10851092. 43. Yamada A, Fujii S, Daiko H, Nishimura M, Chiba T, et al. Aberrant expression of EZH2 is associated having a poor outcome and P53 alteration in squamous cell carcinoma with the esophagus. Int J Oncol 38: 345353. 44. Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N, et al. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 23: 57595769. 45. Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, et al. Get of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell ten: 191202. 9 ~~ ~~ Several myeloma is amongst the most common hematologic malignancies with poor prognosis, characterized by neoplastic proliferation of monoclonal plasma cells. The incidence of MM in created countries is about 57 instances per 100 000 folks. Regardless of comprehensive analysis efforts more than the final two decades, the threat things of MM remain to become established. A lot of case-control and cohort research to date have recommended that numerous environmental elements may very well be linked with all the danger of MM, such as ionizing radiation, benzene and agricultural occupation. The relationship involving autoimmune illness and hematopoietic malignancies was initially postulated in 1964. Nonetheless, the concern of regardless of whether autoimmune illnesses improve the incidence of MM remains controversial. On the basis of animal models of MM, it truly is recommended that repeated antigenic stimulation in the immune method plays a crucial function in MM improvement. Several research have confirmed an association of lymphoma with autoimmune circumstances, including rheumatoid arthritis, systemic lupus erythematosus, and autoimmune hemolytic anemia, while the underlying pathogenesis is unclear. Similarly, the partnership in between MM and autoimmune illness has been a long-term topic of investigation, but inconsistent outcomes have already been obtained to date. The principle aim of this meta-analysis was to estimate the comparative danger of building MM in RA patients versus the general population. Two more goals were to discover the variation in the association of RA and MM amongst subgroups of interest and to investigate if there is an association among MM and also other autoimmune illnesses. Approaches Search Method A literature search was carried out with PubMed, EMBASE and Net of Science using the following search terms: rheumatoid arthritis, autoimmune illness, etiology, epidemiology, Multiple Myeloma in Rheumatoid Arthritis risk factors, numerous myeloma, cancer, malignancy. The final search approach in PubMed was attached as appendix. The final literature search was performed on December 25, 2013. We also searched annual meeting abstracts of the American Society of Hematology from 2004 to 2013 to identify eligible unpublished data. All references cited inside the retrieved articles had been on top of that reviewed to indentify extra eligible research.