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IC-treated children (5 wheeze, 9 respiratory symptoms other than wheeze, 4 without chronic symptoms) had lower median (interquartile range) EBT levels than IC-untreated children (n?=?280) [EBT: 31.7 (30.1�C32.5) vs. 32.6 (31.4�C33.4), P?=?0.027]. Duplicate EBT measurements were highly reproducible (ICC?=?0.94). In a multiple linear-regression model, EBT was explained by age, weight, duration of EBT measurement, FENO, and ambient temperature (r?=?0.63, P?TRIB1 diffusion http://www.selleckchem.com/products/MK-2206.html capacity for carbon monoxide (DLCO) after exercise has been reported in healthy adults. There is limited information for post-exercise DLCO available in children either in health or in disease. To evaluate (1) reproducibility of DLCO measures in children, (2) differences in DLCO between elite athletic swimmers (AS), stable cystic fibrosis patients (CF), and healthy controls (Con) at rest; and (3) after a maximal treadmill exercise test. Participants performed spirometry and DLCO at baseline, a maximal treadmill exercise test and repeated DLCO measures for 2?hr after cessation of exercise. The mean (SD) co-efficient of variation between baseline DLCO tests was 2.49% (1.86%). In girls, the mean baseline DLCO (ml/min/mmHg) was 18.61 (4.15) in CF, 22.32 (4.79) in controls and 27.18 (5.33) in AS. In boys: 23.68 (5.31) in CF, 28.09 (9.95) in controls and 37.75 (9.46) Ibrutinib manufacturer in AS. Baseline DLCO was significantly higher in AS than in CF patients (P?