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As shown in Table 5, only aCL and aPS/PT antibodies presented an elevated risk for obstetric complications (OR 7.4 [95% CI 1.6�C34.5] and OR 7.4 [95% CI 1.5�C35.2], resp.). Table 5 Diagnostic accuracy of aPL for pregnancy loss as defined by APS classification criteria. In our group of 169 patients, 12 (6%) had a history of thrombosis and the prevalence of all tested aPL was higher among them as compared to healthy controls (P Venetoclax APS. The question MMP23B arises whether the same profile of aPL occurs in APS patients with a history of thrombosis compared to obstetric APS. There is general consensus to screen for LA, aCL, and anti-��2GPI, but the role of other autoantibodies remains controversial. Therefore, the necessity to perform more cohort studies in order to determine the incidence of noncriteria aPL in pregnancy loss was suggested [26]. Since then, our group focused on evaluating the prevalence of aPS/PT antibodies among female patients experiencing different obstetric complications during their pregnancies. We found Ibrutinib concentration an overall prevalence of aPS/PT of 13.0%, aCL of 12.4%, LA, and anti-��2GPI less than 8.0% in our group of patients with obstetric complications characteristic for APS. Both aPS/PT and aCL were significantly more prevalent in our cohort of patients compared to healthy blood donors. However, aCL correlated only with late pregnancy morbidity and prematurity while aPS/PT were the only antibodies associated with early recurrent pregnancy loss, as well as with late pregnancy morbidity and prematurity. Our findings are in line with Clark et al. [27] who suggested that aCL-associated early recurrent pregnancy loss be withdrawn from the classification criteria due to inconsistent prevalence of aCL in this population and an increasing body of evidence points to the fact that this clinical manifestation of APS is distinct from late loss or early delivery with placental infarction. However, according to our results, determining aPS/PT in association with early recurrent pregnancy loss may be beneficial. We found 7% (11/169) of patients to be aPS/PT positive and negative for all other tested aPL and 63% (7/11) of them experienced early recurrent pregnancy loss.