Purge SKAP1 Issues Totally

Genotype at 5-HTTLPR was determined for each sample as previously described (Bradley et al., 2005). Of the sample, 9.2% were homozygous for the short allele (ss), 34.2% were heterozygous (sl), and 56.6% were homozygous for the long allele (ll). Consistent with prior research (Hariri et al., 2005), genotyping results were used to form two groups of participants: those homozygous for the long allele (n = 172) and those with either 1 or 2 copies of the short allele (n = 132). Among the 332 participants who provided a saliva sample, 5.12% (n = 17) had a ��very long�� variant of 5-HTTLPR. Because the activity of this variant on the hypothesized Saracatinib molecular weight associations has not been well characterized, these youths were excluded from the data analyses. Data Analysis Plan All analyses were limited to the 304 main trial participants who, in addition to the baseline assessment, consented and provided a valid saliva sample for DNA analysis. Descriptive statistics summarized study variables. In addition, bivariate analyses examined associations between control variables, 5-HTTLPR group (i.e., s allele group vs. ll allele group), psychosocial factors associated with managing stressful experiences (i.e., social support and coping), RD group (i.e., low vs. high) and depressive symptoms (i.e., low vs. high). Associations were assessed using Pearson��s correlations and Chi-square analyses. Variables significant at the p �� 0.10 in bivariate analyses were entered into a multivariable hierarchical logistic regression predicting high depressive symptoms (Hosmer and Lemeshow, 2000), controlling for age and clinic. In the first step, psychosocial correlates were entered into the model. In the second step, RD and 5-HTTLPR were entered into the model. In the final step, to explore whether the association between discrimination and depressive symptoms differed as a function of 5-HTTLPR group, an interaction between discrimination group and 5-HTTLPR group was entered in at this step of the regression model. Results Sample Description Descriptive statistics for all measures are presented in Table ?Table11. The majority was still in high-school or had only completed some high-school at enrollment (53.9%). Many reported living with their mother only (42.9%), and approximately a quarter had a job for which they were paid. Many of the participants were recruited from a county health department STD clinic (n = 154), others were recruited from a reproductive health clinic (n = 119), and the remaining participants were recruited from an adolescent reproductive health clinic in a public hospital (n = 31). Of the 304 participants in this study 82.2% (n = 250) endorsed experiencing a least one of the 13 forms of RD on in the past year. Table 1 Descriptive statistics of the study sample on study variables (N = 304).