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In the present study, the mean serum level of IL-18 in patients with extensive AA was significantly higher than that in the control subjects (P?PTPRJ of IL-18 in AA see more may be different from those in psoriasis, as IL-18 does not reflect only T cells and its precursor is expressed by epithelial cells throughout the body (13). Second, there may be a lag phase between disease severity and the circulating IL-18 level as IL-18 increase IFN-�� production, such that the serum level may not reflect the current disease state. There have been no studies on association between IL-18 and AA; thus, additional studies are required to determine its meaning. In the present study, we demonstrated that higher levels of sIL-2R and lower levels of IL-18 at baseline were associated with a poor prognosis in patients with AA. Additional serial follow-up measurements of the serum concentrations of sIL-2R and IL-18 could lead to the development of rapid, reliable, and click here non-invasive prognostic markers. Table S1. Comparison of the serum cytokine levels in patients with extensive alopecia areata, patients with localized alopecia areata, and control subjects. Table S2.Comparison of the baseline serum levels of IL-18 and soluble IL-2 receptor in the patients and controls. Figure S1.Serum levels of IL-18 in the controls and the patients with extensive alopecia areata. Figure S2.Changes in the serum level of soluble IL-2 receptor after combined therapy with cyclosporine and steroids Methods. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. ""Since Wells and Smith first described cases of eosinophilic cellulitis (Wells syndrome; WS) in 1979, it has been noted that some but not all patients with WS present with eosinophilia. In the face of idiopathic persistent eosinophilia patients will also then fall within the hypereosinophilic syndrome (HES), which represents a multifarious spectrum of disorders of varying severity, causes and outcomes.