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1%) (MD slope non-Cisplatin worsening group). In the MD slope worsening group, age (66.9 vs 62.6 years, P=0.0370), proportion of female (P=0.0324), and degree of refraction (?1.9 D vs ?3.5 D, P=0.0048) were significantly higher as compared to the MD slope non-worsening group. However, there were no significant differences between the two groups in terms of initial MD value (?6.60 dB vs ?7.48 dB, P=0.1916). A comparison of IOP between worsening and non-worsening group revealed no obvious differences in mean IOP (13.2 mmHg vs 13.5 mmHg, P=0.3992) or maximum IOP (16.9 mmHg vs 16.7 mmHg, P=0.8147) during follow-up, but there were significant differences between the two groups in terms of baseline IOP (15.7 mmHg vs 17.2 mmHg, P=0.0107), reduction rate of IOP during follow-up (14.9% vs 20.3%, P=0.0066), minimum IOP (10.2 mmHg vs 11.0 mmHg, P=0.0161), and the standard deviation of IOP during the follow-up period (1.7 mmHg vs 1.4 mmHg, P=0.0309). The fluctuations in IOP are smaller for patients with NTG than for those with POAG, both for patients with worsening of the MD slope (NTG: 1.7��0.9 mmHg vs POAG: 2.2��0.7 mmHg) and for those in whom no such worsening was evident (NTG: 1.4��0.5 mmHg vs POAG: 1.7��0.5 mmHg) (Table 2). Table 2 Associations between different factors and worsening of the MD slope Multiple logistic regression analysis was applied IOP value over follow-up, IOP reduction rate, long-term IOP fluctuation, initial MD value, and refraction that was not affected by multicollinearity, as the objective variable against the presence/absence of MD slope worsening. The results showed significant association between IOP reduction rate (odds ratio [OR]: 0.97, 95% confidence interval [CI]: 0.94�C0.99, P