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Sentinel node biopsy was performed using a combination technique with blue dye and radioisotope injections. The results shown in Table 1 show a significantly greater number of nodes taken with ANS compared with SNB. A significantly higher proportion of patients having SNB had a positive node (22% vs. 9.9%) despite similar baseline tumour characteristics (tumour size, grade and NPI) in SNB and ANS groups, and a greater number of positive nodes following ANC in the ANS group. These results suggest that SNB is more accurate at detecting positive nodes even Fulvestrant chemical structure in low volume axillary disease. Data from 5?years (approx 500 patients) will be presented. ""Methods for intra-operative node assessment can avoid delayed axillary lymph node dissection (ALND) in a proportion of sentinel lymph node biopsy (SLNB) patients. Both frozen section and imprint cytology are inconsistent and of variable sensitivity compared to paraffin embedded H&E sections and have not yet been surpassed by molecular assays. Modern approaches to axillary management can contribute to reduction in absolute numbers of isolated completion ALND cases without intra-operative assessment. A retrospective analysis was undertaken of 443 patients eligible for SLNB with clinically node negative tumours Alizarin from further analysis together with 15 patients undergoing single stage ALND (level I/II) due to age or co-morbidity. Most SB203580 ic50 of the remaining 357 patients had an axillary ultrasound examination (301/357) with 49 proceeding directly to ALND based on positive nodal core biopsy (40), suspicious nodes with (6) or without (3) a negative biopsy. Amongst 308 patients undergoing SLNB, 73 were node positive (23%) and required completion ALND. Just over half these had an isolated delayed ALND (40), whilst 33 patients had ALND with an additional surgical procedure (re-excision, mastectomy with or without IBR). The recall rate for delayed ALND alone was