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However, there is also evidence that increasing practice may strengthen an egocentric strategy use, i.e. a habitual approach to the task (Iaria et al., 2003). Nevertheless, both egocentric and allocentric representation of space recruits a similar network of brain regions, i.e. Dolutegravir the precuneus, PCRS, inferior parietal cortices and parahippocampal cortex (Maguire et al., 1998, Aguirre et al., 1996, Weniger et al., 2010, Neggers et al., 2006?and?Spiers and Maguire, 2007). The PCRS (Maguire, 2001) as well as the parahippocampal cortex (Weniger et al., 2010?and?Weniger and Irle, 2006), having been proposed as pivotal structures for the translation between egocentric and allocentric frames of memory, showed relative hypoactivation in the schizophrenia patients of the present study. Converging evidence has shown that the hippocampus is a key structure for allocentric navigation and memory formation (O'Keefe and Nadel, 1978, Iaria et al., 2003, Holdstock et al., 2000, King et al., 2002, Bohbot et al., 2004, Barry et al., 2006, Bohbot et al., 2007?and?Etchamendy et al., 2012). The whole-brain analysis of the present study did not reveal a significant cluster within the hippocampus, suggesting that allocentric processes were not prevalent during trials 1 and 2. However, control subjects showed activation Methisazone of the right hippocampus during trial 3 and a significant right hippocampal signal decrease from trial 3 to trial 4, suggesting that they may have had successfully translated egocentric information into an allocentric survey perspective during trial 3. In contrast to control subjects, participants with schizophrenia showed a flat signal course of the right hippocampus across Obeticholic Acid trials (mean ��-values for all trials?