Our Advantage Of Oxygenase
1-[4-(2-Hydroxyl-2-oxoethoxy)phenyl]-1-(n-pentyl)--3-(pyridine-2-yl)urea (20a): 1H NMR Oxygenase (DMSO-d6, 300?MHz), ��: 8.The year 2007 (michael, 1H, ArH), 7.94 (d, 1H, J=8.7?Hz, ArH), 7.67�C7.72 (meters, 1H, ArH), 7.28 (deb, 2H, J=8.7?Hz, ArH), 6.98 (utes, 1H, ?CONH?), 6.92�C7.10 (meters, 3H, ArH), 4.57 (s, 2H, ?COCH2?), 3.Fifty nine (t, 2H, J=7.5?Hz, ?CH2?), 1.43 (michael, 2H, ?CH2?), 1.23�C1.Twenty five (mirielle, 4H, ?CH2?��2), 0.83 (t, 3H, J=6.9?Hz, ?CH3); m/z 358 [M+H]+; HR-MS calculated for C19H23N3O4: m/z 358.1763 [M+H]+, identified 358.1761. 1-[4-(2-Hydroxyl-2-oxoethoxy)phenyl]-1-(n-pentyl):3-(5-methylpyridine-2-yl)urea (20b): check details 1H NMR (DMSO-d6, 300?MHz), ��: 12.Goal (azines, 1H, ?OH), 7.Ninety days (mirielle, 1H, ArH), 7.83 (d, 1H, J=8.4?Hz, ArH), 7.Fifty three (dd, 1H, J1=2.1?Hz, J2= 8.4?Hz, ArH), 7.Thirty (n, 2H, J=9.0?Hz, ArH), 7.01�C7.Apr (michael, 3H, ArH, ?CONH?), 4.3 (ersus, 2H, ?COCH2?), 3.59 (to, 2H, J=7.2?Hz, ?CH2?), 2.16 (utes, 1H, ?CH3), 1.40�C1.44 (mirielle, 2H, ?CH2?), 1.24 (meters, 4H, ?CH2?��2), 0.Eighty two (t, 3H, J=6.6?Hz, ?CH3); m/z 372.2 [M+H]+; HR-MS determined regarding C20H25N3O4: m/z 372.191 [M+H]+, found 372.1918. 1-[4-(2-Hydroxyl-2-oxoethoxy)phenyl]-1-(n-pentyl)--3-(5-chloropyridine-2-yl)urea (20c): 1H NMR (DMSO-d6, 300?MHz), ��: 13.05 (azines, 1H, ?OH), 8.12 (deb, J=2.7?Hz, ArH), 7.Ninety seven (d, 1H, J=9.0?Hz, ArH), 7.Eighty two (dd, 1H, J1=2.7?Hz, J2=9.0?Hz, ArH), 7.29�C7.Thirty-two (m, 3H, ArH, ?CONH?), 7.02 (d, 2H, J=8.7?Hz, ArH), 4.Seventy three (utes, 2H, ?COCH2?), 3.Sixty (big t, 2H, J=7.2?Hz, ?CH2?), 1.Forty three (m, 2H, ?CH2?), 1.Twenty-four (michael, 4H, ?CH2?��2), 0.Eighty three (t, 3H, J=6.6?Hz, ?CH3); m/z 392 [M+H]+; HR-MS worked out regarding C19H22ClN3O4: m/z 392.1373 [M+H]+, identified 392.1372. 1-[4-(2-Hydroxyl-2-oxoethoxy)phenyl]-1-(n-pentyl)-3-(5-hydroxylformylpyridine-2-yl)urea (20d): 1H NMR (DMSO-d6, 300?MHz), ��: Thirteen.Drive (ersus, 2H, ?OH��2), 8.Sixty four (d, 1H, J=2.1?Hz, ArH), 8.20 (m, 1H, ArH), 8.05 (d, 1H, J=8.7?Hz, Fasudil ic50 ArH), 7.52 (ersus, 1H, ?CONH?), 7.32 (d, 2H, J=8.7?Hz, ArH), 7.Drive (d, 2H, J=8.7?Hz, ArH), 4.74 (utes, 2H, ?COCH2?), 3.62 (t, 2H, J=6.9?Hz, ?CH2?), 1.44 (michael, 2H, ?CH2?), 1.24 (meters, 4H, ?CH2?��2), 0.Eighty three (capital t, 3H, J=6.9?Hz, ?CH3); m/z 402 [M+H]+; HR-MS calculated with regard to C20H23N3O6: m/z 402.1669 [M+H]+, found 402.1660.
