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The rate was selected based on a combined total of 20% representing the five elements suggested by SIR that contribute to clinical failure: technical failure (3%), recurrent PE (5%), filter embolization (Selleckchem Docetaxel trauma (20.5%), and hypercoagulopathy (22%; Table 1). The mean procedure time for filter placement was 17.8 minutes �� 10.3 (range, 3�C90 min), and the mean fluoroscopy time was 3.6 minutes �� 3.1 (range, 1�C32 min; Table 2). The most common vascular access site used for placement was the right common femoral vein (55%), followed by the right internal jugular vein (35%). The mean IVC diameter at the site of placement was 22.2 mm �� 3.1 (range, EX 527 purchase 12.7�C27.8 mm). The disposition of the 200 patients in the DENALI study is outlined in Figure 2. Filters were retrieved in 108 patients, and 24 patients were removed from the study before completion; of these, 14 patients died from causes unrelated to the IVC filter, one withdrew consent to participate in Vatalanib (PTK787) 2HCl the study, seven were lost to follow-up, and two were discontinued from the study at the discretion of the investigator. Forty-nine patients still had an indication for the filter to remain in situ during their 6-month follow-up clinic visit. Filters remained implanted in 92 patients. Technical success of filter placement was achieved in 99.5% (n = 199) of the patients enrolled in the trial (Table 2). One filter was introduced but could not be deployed, and a second filter was successfully deployed in the patient without clinical sequelae. In addition, a successfully deployed device was moved inadvertently with a guide wire during postprocedural imaging; this was not considered a technical failure, and the filter was immediately retrieved and replaced with a second filter at the discretion of the operator. CSP��ie, freedom from placement failure, complications associated with filter placement, subsequent PE, filter embolization, vena cava occlusion, or filter- or procedure-related death��was achieved in 94.5% of patients (172 of 182; 95% CI, 90.1%�C97.3%) in the ITT population (Table 3).