13 Navitoclax Discussion Tips

?2). Eleven patients had more complex procedures consisting in recreation of 1 commissure (n?=?9) or 2?commissures (n = 1) and triangular resection of the leaflet free edge (n = 1). The commissures were recreated by adjunction of 2?separate patches of glutaraldehyde preserved autologous pericardium to the opened area of the valve (Fig.?2). Seventeen of the 123 patients (15%) underwent the following concomitant 19 procedures: coarctation repair (n?= 8), hypoplastic aortic arch repair (n = 1), ventricular septal defect repair (n = 6), atrial septal defect repair (n = 3), and a mitral valve repair and left atrial size reduction (n = 1). Hospital mortality was defined as death prior to hospital discharge or within 30 days of the surgery. Late mortality was defined Bumetanide as death after discharge or more than 30 days from the first valve intervention. Early re-interventions were defined as any operation on a previous valve intervention or replacement before hospital discharge and were considered separate to late re-operations occurring after hospital discharge. Reporting of valve-related outcomes, such as valve thrombosis and bleeding events, were based on published guidelines (6). Follow-up information was gathered from the hospital database or collected from their referring cardiologists. Statistical analysis was performed using?Stata version 11.0 (StataCorp, College Station, Texas). Symmetric continuous variables were summarized as mean ��?SD, and median (interquartile range) otherwise. Risk factors for the following time-related outcomes were examined using Cox regression analysis: mortality, Navitoclax nmr re-intervention, valve replacement, moderate or greater restenosis or re-intervention, moderate or greater ABT-199 supplier regurgitation, and failure of event-free long-term outcome. For all endpoints, time was measured starting from the day of the initial procedure. For the regurgitation endpoint, patient times were considered to have been censored in the event of?a?first re-intervention, and similarly, all?non-mortality endpoints were considered to have been censored in the event of late death. The variables examined are listed in Table?2. Where feasible, variables identified by univariate analysis as the ones most likely to be associated with?the given endpoint (hazard ratio [HR]: >2.0 or HR?