The Best, The Negative As well as OPHN1

Combining two keywords, as appropriate, a total of 786 articles were initially screened and 103 were further analysed. Original data were considered as a higher level of pertinent information, including experimental data. Review articles were considered as secondary level information and are rarely cited in this manuscript. The available guidelines on the topic were screened with particular attention. Many prognostic factors have been proposed for acute Pomalidomide datasheet pericarditis. According to a literature review [18], [19], [20]?and?[21], several clinical features are usually considered to be more frequently associated with an increased risk of short-term complications or a specific diagnosis: fever?>?38?��C [22]; subacute onset (symptoms developed over a period of several days or weeks) [23]; immunodepression [23]; trauma [24]; oral anticoagulant therapy [25]; myopericarditis (pericarditis with clinical or serological evidence of myocardial involvement) [26], [27]?and?[28]; large pericardial effusion (effusion with a diastolic echo-free space?>?20?mm wide) or cardiac tamponade [29]?and?[30]; lack of initial response to aspirin or NSAIDs within 1 week [18]; and corticosteroid use [31]. Some clinical features (fever?>?38?��C, OPHN1 subacute course, large effusion or tamponade and aspirin or NSAID failure) have also been proposed as prognostic factors for higher risk of specific causal conditions www.selleckchem.com/products/a-1210477.html and complications [32]?and?[33], and help with risk stratification when deciding about hospitalization. More recently, biological markers were proposed to stratify the risk, especially troponin, even if mildly elevated [34], and C-reactive protein (CRP) [35]. Some clinical conditions may favour a higher probability of autoimmune disease, especially female sex [32]. Although sinus tachycardia is frequently observed in patients with pericarditis [16], tachycardia was not clearly identified as a prognostic marker. Recently, our group identified a link between HR and CRP [36] (Fig. 1). In this retrospective study of 73 patients (median age, 38 years; interquartiles 28�C51), median HR was 88.0 beats per minute on admission (interquartiles 76.0�C100.0) and 72.0 beats per minute on discharge (65.0�C80.0). HR on admission was significantly correlated with CRP peak (p?