Our study therefore shows that Puma is the major sentinel/sensor of incoming viruses to convey an apoptotic signal to MOMP

Nonetheless none of the previous research utilised Puma knock-out or knock-down AVE-0991 methods to demonstrate the involvement of Puma in virus-induced apoptosis. Anti-actin as 1254053-43-4 manufacturer loading and anti-SFV-C as an infection controls in (B). The p values are the subsequent: 3T9 sh-Puma versus 3T9 sh-Ctrl: p = .008 for 6 h, p