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The periapical radiograph does not provide a very real picture of the bone situation. However, can help the clinician to monitor changes in crestal bone levels. Conclusion and clinical implications There is a statistically significant difference (P?selleckchem C�� Granda, University of Milan, Milan, Italy Background Etiologically, the loss of teeth in the posterior maxillary area can lead to adverse consequences concerning Trametinib the function of the maxillo-dental musculoskeletal apparatus. Dental implant prosthetic treatment can be an alternative to traditional restorations such as dentures or dental bridges; however, an adequate bone volume is clinically needed in case of a fixed implant-supported prosthesis. Grafting the maxillary sinus combined with the elevation of the Schneiderian membrane was proposed to re-establish an ideal quantity and quality of bone to assess implant placement. The surgical protocol has gone through several developments during the years, and variables that could influence the treatment outcome have emerged. Aim/Hypothesis The aim of the present study was to retrospectively evaluate the survival rate of dental implants placed in regenerated atrophic maxillary sinuses. A database including 203 patients who Ibrutinib cell line received 589 dental implants after 246 sinus lift procedures was analysed to assess the influence of hypothetical significant predictors of implant failure. Material and methods Five hundred and eighty nine dental implants were placed in 203 patients after 246 lateral sinus elevation surgeries. Inclusion criteria were both mono and bilateral partial edentulism associated with different degrees of vertical and horizontal bone loss of lateral-posterior maxilla (according to class II to VI Cawood & Howell atrophy classification) with pneumatization of maxillary sinus that requires sinus floor elevation procedures for implants placement purposes. Particularly, only patients presenting a residual radiological bone height between 1 and 6?mm below the maxillary sinus were treated with a lateral antrostomy approach and were then considered in the present study. A total of 346 (58.7%) implants were placed in DBBM, 24 (4.1%) implants in autogenous bone graft and 219 (37.2%) into a 1?:?1 mixture of DBBM and autogenous bone graft. 204 (34.