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Variability in gene expression underlies incomplete penetrance. Nature 463: 913?18. Roberts SB, Sanicola M, Emmons SW, Childs G. 1987. Molecular characterization with the histone gene loved ones of Caenorhabditis elegans. J Mol Biol 196: 27?eight. Roberts SB, Emmons SW, Childs G. 1989. Nucleotide sequences of Caenorhabditis elegans core histone genes: Genes for distinctive histone classes share popular flanking sequence components. J Mol Biol 206: 567?77. Robinson MD, McCarthy DJ, Smyth GK. 2010. edgeR: a Bioconductor package for differential expression analysis of digital gene expression information. Bioinformatics 26: 139?40. Shin H, Hirst M, Bainbridge MN, Magrini V, Mardis E, Moerman DG, Marra MA, Baillie DL, Jones SJ. 2008. Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags. BMC Biol 6: 30. Whittle CM, McClinic KN, Ercan S, Zhang X, Green RD, Kelly WG, Lieb JD. 2008. The genomic distribution and function of histone variant HTZ-1 through C. elegans embryogenesis. PLoS Genet 4: e1000187. Yuzyuk T, Fakhouri TH, Kiefer J, Mango SE. 2009. The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Dev Cell 16: 699?ten. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, et al. 2003. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4: R28.Data accessThe sequencing information from this study have already been submitted towards the NCBI Sequence Read Archive (SRA; http://www.ncbi.nlm.nih. gov/sra/) below the accession numbers listed in Supplemental Table S1.AcknowledgmentsWe thank Pnina Strasbourger for help in generating RNA-seq libraries; Calvin Mok and Adam Warner for beneficial discussions; and John Murray and Don Moerman for comments around the manuscript. This perform was supported by National Institutes of Wellness (NIH) grants U01HG004263 and R01GM072675 to R.H.W. and by the William H. Gates Chair of Biomedical Sciences.Affective and social neuroscience have rapidly advanced through the final 25 years (Baron-Cohen et al., 2013; Dbiec et al., 2014).Ence 293: 2087?092. Nucleotide sequences of Caenorhabditis elegans core histone genes: Genes for unique histone classes share common flanking sequence components. J Mol Biol 206: 567?77. Robinson MD, McCarthy DJ, Smyth GK. 2010. edgeR: a Bioconductor package for differential expression evaluation of digital gene expression information. Bioinformatics 26: 139?40. Shin H, Hirst M, Bainbridge MN, Magrini V, Mardis E, Moerman DG, Marra MA, Baillie DL, Jones SJ. 2008. Transcriptome evaluation for Caenorhabditis elegans based on novel expressed sequence tags. BMC Biol 6: 30. Whittle CM, McClinic KN, Ercan S, Zhang X, Green RD, Kelly WG, Lieb JD. 2008. The genomic distribution and function of histone variant HTZ-1 throughout C. elegans embryogenesis. PLoS Genet 4: e1000187. Yuzyuk T, Fakhouri TH, Kiefer J, Mango SE. 2009. The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos. Dev Cell 16: 699?10. Zeeberg BR, Feng W, Wang G, Wang MD, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, et al. 2003. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 4: R28.Information accessThe sequencing data from this study have already been submitted to the NCBI Sequence Read Archive (SRA; http://www.ncbi.nlm.nih.