Ociation in between CDI recurrences and age more than 70 years (p = 0.283), albumin worth

Ociation involving CDI recurrences and age more than 70 years (p = 0.283), albumin value significantly less than three g/dL (p = 0.201), leukocytes quantity greater than 15000/cmm (p = 0.552), presence of acute renal insufficiency (p = 0.236) or concomitant systemic antibiotic therapy (p = 0.371). Conclusions CDI recurrences have been not correlated with older age, presence of a neoplastic illness, administration of concomitant systemic antimicrobial therapy, history of one more CDI recurrence, severity of CDI, expressed by reduce albumin, higher number of leukocytes or presence of acute renal insufficiency. Associating tigecycline did not lower the recurrences in comparison to traditional therapy (metronidazole or vancomycin). A113. Differential diagnosis of staphylococcal and tuberculous osteodiscitis ?case report Adina Elena Ilie1, Sftica-Mariana Pohrib1, Alina Cristina Negu1,2, MariaSabina Tache1, Maria Magdalena Mooi1, Oana Sndulescu1,two, Ion Aurel Iliescu3, Adrian Streinu-Cercel1,2 1 National Institute for Infectious Ailments "Prof. Dr. Matei Bal", Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3University Emergency Hospital of Bucharest, Bucharest, Romania Correspondence: Sftica-Mariana Pohrib (pohrib.mariana@yahoo.com) BMC Infectious Ailments 2016, 16(Suppl four):A113. Background Together with the incidence of tuberculous osteodiscitis around the rise, Mycobacterium tuberculosis is presently viewed as the second etiological agent of osteodiscitis. Case report A 65 year-old female presented to our clinic for low-grade fever with intense back pain that progressed towards the medial side of both reduced limbs, with paresthesia within the left leg and Sical examination at admission reveals typical general state, no fever, conscious discomfort in the correct iliac fossa dating back 14 days. Healthcare history revealed stage two hypertension, appropriate sylvian hemorrhagic stroke (2010) with left sequel hemiparesis and bilateral pulmonary Youngsters Timioara, ten days just before presentation in our clinic for: emphysematous acute thromboembolism (2010). The clinical exam showed left sequel hemiparesis, slightly diminished deep tendon reflexes on the left side and intensely impaired mobility. The lab reports showed acute inflammatory syndrome, coagulation title= cbe.14-01-0002 problems and elevated serum creatinine. A lumbosacral spine MRI scan carried out one day before admission described L4-L5 spondylodiscitis with huge anterior epidural abscesses and correct paravertebral abscess. It was initially labeled as likely staphylococcal osteodiscitis and therapy was initiated with rifampin and levofloxacin with no clinical improvement and persistence of low-grade fever after 5 days, when rifampin was changed to linezolid. The evolution was apparently favorable (afebrile with decrease in biological inflammation markers), but the MRI carried out immediately after one particular month of therapy revealed lesion progression. She was transferred to neurosurgery exactly where a L4-L5 laminectomy was performed and for the duration of surgery a gray-yellow mass suggestive for Mycobacterium tuberculosis (TB) etiology was located. Wound and title= acer.12126 blood cultures were negative, Gram stain showed no bacteria and Ziehl-Neelsen stain failed to show acid-fast bacilli. Nevertheless, the histopathologic examination was extremely suggestive for Mycobacterium tuberculosis etiology and antiTB therapy was initiated with all the 4-drug-regimen: isoniazid, rifampin, pyrazinamide, ethambutol, with clinical and biological improvement. So far, the patient has undergone anti-TB therapy for three months with neurological improvement along with a repeat title= journal.pone.0073519 MRI scan is scheduled when the patient completes five months of therapy. Conclusions Inside the presented case, the clinical an.Ociation between CDI recurrences and age over 70 years (p = 0.283), albumin worth significantly less than three g/dL (p = 0.201), leukocytes number higher than 15000/cmm (p = 0.552), presence of acute renal insufficiency (p = 0.236) or concomitant systemic antibiotic therapy (p = 0.371).