SMolecular Cancer BiologyFigure 1. Intraindividual heterogeneity between liver metastases as determined by

Intraindividual heterogeneity between liver metastases as determined by different Title Loaded From File mutation status for one or more of the genes TP53, KRAS, BRAF and PIK3CA. Kaplan eier survival curves illustrating time to relapse (left panels) and disease-specific survival (right panels) after liver surgery for metastatic colorectal cancer with respect to mutation status for KRAS, BRAF, KRAS title= 02699931.2015.1049516 and BRAF combined, PIK3CA and TP53 (n 5 151 in each panel). A patient was classified as harboring a gene mutation as long as it was present in at least one lesion. pvalues are from log-rank tests.Mutation status and prognosis after liver resectionTo evaluate the prognostic impact of the mutations described above in patients treated with liver resections, we excluded patients who had undergone a previous liver resection (n 5 13) before inclusion in the present study, leaving a total of 151 patients. In univariate analyses (Fig. 2), we found KRAS and BRAF mutations both to be associated with reduced median TTR (7 vs. 22 and 3 vs. 16 months; p title= srep43317 Comparing all the four treatment groups together, a significant effect on TRR (p