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Biochemical and Acco, and marijuana addiction, and initial research around the use of metabolic abnormalities in articular cartilage from osteo-arthritic human hips. Xie L, Lin AS, Levenston ME, Guldberg RE. Quantitative assessment of articular cartilage morphology via EPIC-microCT. Osteoarthritis Cartilage. 2009;17:313?0. 40. Yoo WJ, Cheon JE, Lee HR, Cho TJ, Choi IH. Physeal growth arrest by excessive compression: histological, biochemical, and micro-CT observations in rabbits. Clin Orthop Surg. 2011;3:309?4. 41. Douni E, Sfikakis PP, Haralambous S, Fernandes P, Kollias G. Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols. Arthritis Res Ther. 2004;6:R65?2. 42. Tamura T, Shirai T, Kosaka N, Ohmori K, Takafumi N. Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption. Eur J Pharmacol. 2002;44:81?. 43. Tamura T, Kosaka N, Ishiwa J, Sato T, Nagase H, Ito A. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis Cartilage. 2001;9:257?3. 44. CRs in controls vs. SZ in block 9 of conditioning. UR ?No Pastoureau P, Leduc S, Chomel A, De Ceunink F. Brandt KD, Smith G, Kang SY, Myers S, O'Connor B, Albretch M. Effects of diacerhein in an accelerated canine model of osteoarthritis. Osteoarthritis Cartilage. 1997;5:438?9.46. Hwa SY, Burkhardt D, Little C, Ghosh P. The effects of orally administered diacerein on cartilage and subchondral title= jir.2011.0103 bone in an ovine model of osteoarthritis. J Rheumatol. 2001;28:825?4. 47. Brahmachari B, Chatterjee S, Ghosh A. Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial. Clin Rheumatol. 2009;28:1193?.Submit your next manuscript to BioMed Central and take full advantage of:?Convenient online submission ?Thorough peer review ?No space constraints or color figure charges ?Immediate publication on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submitMartelli et al. BMC Veterinary Research (2016) 12:77 DOI 10.1186/s12917-016-0700-RESEARCH ARTICLEOpen AccessImpact of maternally derived immunity on piglets' immune response and protection against porcine circovirus type 2 (PCV2) after title= journal.pone.0077579 vaccination against PCV2 at different agePaolo Martelli1*, Roberta Saleri1, Giulia Ferrarini1, Elena De Angelis1, Valeria Cavalli1, Michele Benetti1, Luca Ferrari1, Elena Canelli1, Paolo Bonilauri2, Elena Arioli3, Antonio Caleffi3, Heiko Nathues4 and Paolo BorghettiAbstractBackground: This study was aimed at evaluating the clinical protection, the level of Porcine circovirus type 2 (PCV2) viremia and the immune response (antibodies and IFN- secreting cells (SC)) in piglets derived from PCV2 vaccinated sows.4;12:878?6. 37. Mankin HJ, Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971;53:523?7. 38. Palmer AW, Guldberg RE, Levenston ME. Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography. Proc Natl Acad Sci USA. 2006;103:19255?0. 39. Xie L, Lin AS, Levenston ME, Guldberg RE.