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1) but significantly lower probability than both medial and ventral MGB (p??0.1). Across all subdivisions, those neurons which showed the highest probability of firing to the click http://www.selleckchem.com/ stimulus were also those which had the highest firing rates; however there was no obvious correlation between the neuron��s Carfilzomib manufacturer probability of firing and its tonal response properties (CF, bandwidth, or minimum threshold). Fig.?5 shows the distribution of spontaneous rates across the different subdivisions. The medial and dorsal MGB subdivisions were found to have the greatest proportion of cells which showed virtually no spontaneous firing (77% and 91% respectively), and the maximum spontaneous firing rate in these subdivisions was 15?Hz and 11.5?Hz respectively. In comparison, the distribution of spontaneous rates in the ventral MGB and Pol was broader, with fewer cells showing very low spontaneous firing and maximum spontaneous rates exceeding 30?Hz in both cases. Neurons with low spontaneous rates did not necessarily have a low probability of firing in response to a click (Fig.?6A). While neurons showing low probability of firing tended to have low spontaneous rates (Cefaloridine between probability of firing to a click and the neurons�� first-spike latency to that stimulus (Fig.?6B). In the case of the medial MGB, those neurons which showed the highest probability of response tended to have shorter response latencies (between 5 and 14?ms); however not all medial MGB neurons which had shorter response latencies showed high probability of firing. This pattern was not so apparent for the other subdivisions. Observation of the population PSTHs to click normalised by the spontaneous rate (see Fig.?7) revealed the firing rate immediately returned to baseline following the response in the medial (Fig.?7B) and dorsal MGB (Fig.?7C), whereas in the ventral MGB (Fig.?7A) and Pol (Fig.?7D) the firing rate dipped slightly below spontaneous rate for the period of 75�C275?ms after stimulus onset. The presence of higher spontaneous rates in the ventral MGB and Pol may have made the dip below spontaneous rate more apparent than for the medial and dorsal MGB.