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We have shown that a simple algorithm, based on frequency analysis of bladder pressure, can be used to predict voiding and to provide quantitative data on non-voiding bladder activity and its changes due to pathology. Although the results refer to anesthetized rats, they are promising and warrant further urodynamic investigation to identify if similar patterns occur in non-anesthetized rats and in humans. Neurourol. Urodynam. ? 2014 Wiley Periodicals, Inc. ""To present and describe a non-invasive method to study the origin and development of bladder filling sensation and to evaluate the repeatability Cefaloridine of the method. Eighteen volunteers participated in the study and were given a water loading protocol consisting of 1,000?ml water intake 1?hr before the session and 200?ml every 10?min during the session. Protocol 1: To evaluate diuresis rate, seven participants were asked to void every 15?min and the voided volume was measured. Protocol 2: Eleven volunteers Osimertinib datasheet graded bladder sensation on regular time points, on an empty graph with time on the X-axis and intensity of sensation on the Y-axis. The protocol ended at absolute need to void (maximal intensity) and voided volumes were measured. This protocol was conducted three times with a 10 days interval. Protocol 1: The diuresis rate was not different during the sessions and showed no variation over the studied time period (P?=?0.2). Protocol 2: For an individual, the diuresis rate was not different between the sessions. The curves in all patients showed a continuously increasing bladder PLX-4720 concentration intensity. In seven participants the curve was convex, in the other four, the curve was sigmoidal. For each individual the pattern was constant during the three sessions. A strict water loading protocol induces a constant diuresis. This allows individuals to draw an introspection bladder sensation curve with a specific shape, which can be used as a method to study the development of bladder sensation non-invasively. Neurourol. Urodynam. 33:502�C506, 2014. ? 2013 Wiley Periodicals, Inc. ""To update the 2-year outcomes of the TOMS? transobturator male sling for treating post-prostatectomy urinary incontinence (pRP-UI) in a group of patients previously evaluated at 1 year. We prospectively followed 40 patients with pRP-UI before and 6, 12, and 24 months after implantation of the TOMS? transobturator male sling. Urinary symptoms were evaluated using the following questionnaires: USP, ICIQ, UCLA-PCI (urinary bother domain), PGI-I, and daily pad use. Success was defined as patients wearing no or only one security pad. We also report on any other surgical procedures for treating persistent incontinence during the follow-up period. Of 40 patients included in the 1-year follow-up, seven required additional surgical treatment. In the remaining patients (n?=?33), significant improvement (P?