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The original CCC study reported a best cut-off of 132 to discriminate between children with typical SLI and those with PLI.[7] The study confirmed that the cut-off of 132 remained the most acceptable sensitivity and specificity. The clinical subjects in the Bishop CCC study[7] were different from the present study in terms of age range and diagnosis. Despite these differences, the present Thai study using ROC analysis found that the same cut-off scores optimally discriminated pragmatic impairments in children with ASD from children with typical development. This cut-off can differentiate only children with PLI from typically developing children, not from those with SLI. Therefore, further research is required in the wide range of language disorders samples. The present study found Venetoclax nmr that children with ASD can be differentiated from typically developing children in terms of pragmatic language skills based on the CCC-Thai. This instrument demonstrated acceptable sensitivity and specificity with high PPV and NPV. Therefore, the CCC-Thai is a useful instrument to detect PLI in Thai children with ASD, but cannot www.selleckchem.com/products/MDV3100.html be used as a diagnostic instrument. In the present Thai study we had a heterogeneous sample with regard to children's ability. Therefore we used the VABS to obtain a standardized measure of adaptive functioning. Although the VABS score of adaptive functioning might not exactly represent children's IQs, it is closely correlated with cognitive level (verbal IQ, performance IQ, full-scale IQ or mental age).[12-14] In the present study, 76% of children with ASD had low-functioning ASD (VABS score Histone demethylase between VABS score and CCC score in both low-functioning and high-functioning groups. Further study in high-functioning children with ASD should be done to evaluate whether the CCC-Thai remains a useful instrument for differentiation between subtypes within ASD. The mean age of the ASD group was higher than the typical development group possibly, because the ASD children were required to able to speak in sentences. The previous study suggested that the pragmatic composite score showed significant improvement with age.[10] In contrast, the present study found that the CCC score in the ASD group did not vary with age. Although this study is the first to confirm the usefulness of the CCC in Thai children, there were some limitations. First, all of the discriminant function analysis results were based on clinically diagnosed samples; no standard diagnostic tools such as the Autism Diagnostic Observation Schedule[15] or the Autism Diagnostic Interview�CRevised[16] were used to confirm the diagnosis of ASD. Second, the present study was based solely on parental report.