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Bray�CCurtis similarity was highest between adjacent months �C with a local maximum at 12-month and local minima at 6- and 18- to 20-month lags. The T4-like virus community at SPOT exhibited seasonality, yet the somewhat unexpected persistence of moderately abundant OTUs and predictability of the community add new twists to existing conceptual models of marine viruses. ""4074" "The use of lasers to treat atrophic scarring conditions in darker skin types presents a significant challenge to laser practitioners. Current treatment modalities, including deep dermal peels; ablative; non-ablative; and fractional laser resurfacing and surgical techniques, are limited in skin types IV through VI due to increased risks of hyper- and hypo-pigmentation. This is especially true when attempting to treat large areas of acne scarring. This study investigates the treatment of atrophic scarring with a non-ablative selleck screening library sub-millisecond-pulsed 1,064?nm Nd:YAG laser in darker skin types. To evaluate the safety and efficacy of a sub-millisecond 1,064?nm Nd:YAG laser for the treatment of atrophic scarring in Fitzpatrick skin types III�CVI through retrospective photographic analysis. A retrospective analysis was conducted of all patients (n?=?22) who received sub-millisecond Nd:YAG laser treatments for atrophic scarring over a 6-month period. Patients had Fitzpatrick skin types III�CVI and were treated for the indication of atrophic scarring using the fluence of 14�C16?J/cm2, pulse duration of 300�C500?microseconds and repetition rate of 5�C7?Hz. An average of six treatments was performed Temozolomide research buy on each patient approximately 3 weeks apart and the mean follow-up time after the final DDR1 treatment was 9 months (range of 3�C10 months). Blinded photographic assessments were performed by three independent physicians using photos unlabeled for before and after and arranged in non-chronological order. Reviewers were asked to determine before and after photos and the degree of improvement in scarring, textural change, and post-inflammatory hyper-pigmentation (PIH) secondary to the acne or scarring condition. Degree of improvement was graded using a four-point scale: 0?=?