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A high-SPF photostable sunscreen with high UVA-PF can provide proportionately high protection against multiple cellular damage markers. ""The combination of seawater baths find more and narrowband ultraviolet B (NB-UVB) is a known treatment for psoriasis. This study evaluates two treatment regimens that combine bathing in geothermal seawater and NB-UVB therapy in comparison with NB-UVB monotherapy. Sixty-eight psoriasis patients were randomly assigned to outpatient bathing in geothermal seawater combined with NB-UVB therapy three times a week, intensive daily treatment involving bathing in geothermal seawater combined with NB-UVB therapy, or NB-UVB therapy alone three times a week; treatment period was 6 weeks. Disease severity [Psoriasis Area Severity Index (PASI) and Lattice System Physician's Global Assessment scores], quality of life (Dermatology Life Quality Index) and histological changes were evaluated before, during and after treatment. The primary end point was the proportion of patients who achieved PASI 75 at 6 weeks. At 6 weeks, the percentage of patients who achieved PASI 75 and PASI 90 was significantly greater for both regimens, bathing in geothermal seawater three LMTK2 times a week (68.1% and 18.2%, respectively) and intensive treatment with geothermal seawater (73.1% and 42.3%, respectively) than for NB-UVB monotherapy (16.7% and 0%, respectively) (P?Romidepsin produces longer remission time and permits lower NB-UVB doses than UVB therapy alone. Water-based therapy involving natural thermal springs, hot springs, mineral water, or seawater is currently used to treat psoriasis patients in treatment centres all over Europe [1]. Examples of unique places for water-based therapy are the Dead Sea in Israel, the Kangal hot spring in Turkey and the Blue Lagoon in Iceland. Climatotherapy, such as that received in the Dead Sea area, refers to a combination of sun exposure and bathing in seawater where an important role is attributed to natural UV radiation [2, 3]. To simulate climatotherapy as linked to special geographic settings, a combined treatment with seawater baths and artificial UV irradation (balneophototherapy) was established. Both open prospective studies [4-6] and randomized controlled trials involving a large number of psoriasis patients show the superiority of balneophototherapy over UVB monotherapy [7, 8].