Atypical Nonetheless Potential Sitaxentan Strategies

Statistical methods Continuous data are presented as mean with SD or median with IQR depending on their distribution. Normality was tested using the Shapiro-Wilk test for normality. Categorical data are presented as absolute numbers with percentages. The Wilcoxon-related samples signed rank test was used for comparison of biomarker levels and vital signs between T0 and T1. Effect sizes are presented as Cohen's d.15 The variance between the sepsis severity groups and effect of medication or comorbidities on the response to treatment was tested using the non-parametric Jonckheere-Terpstra test. Missing data were excluded for analysis. All statistical analyses were performed using IBM SPSS Statistics for Windows V.22.0 (IBM Corp, Armonk, New York, USA). A p value of Sitaxentan Results In total, 101 patients were included. Two patients were excluded since informed consent could not be obtained from one patient before T1 and was withdrawn by another patient. The remaining 99 patients were Cell Cycle inhibitor included in the final analysis. Of these patients, 63 presented with sepsis, 30 with severe sepsis and 6 with septic shock at ED admission. Patient characteristics, including comorbidities and medication use prior to ED presentation, are shown in table 2. Patients with severe sepsis more frequently had a history of mild liver disease (p=0.02). Patients with sepsis used diuretics more often (p=0.02). The presumed focus of infection, vital signs and treatment parameters are shown in table 3. The most frequent foci were pulmonic and urogenital. The frequency of these foci did not differ between severity groups. Patients in the septic shock group received more intravenous fluids (3.5?L; IQR 2.9�C5.0?L) compared with those with severe sepsis and those with sepsis (p=0.009). Table?2 Patient characteristics, comorbidity, medication at presentation in the emergency department Table?3 Presumed focus, vital signs and treatment parameters in the emergency department Vital signs Blood pressure at T0 and T1 was inversely related to sepsis severity as blood pressure decreased with increasing severity of sepsis. The results of all vital sign measurements are shown in tables selleck chemicals 3 and 4. Table?2 shows the vital signs for T0 and T1 separated by the sepsis severity groups. Table?4 includes the �ġ�s between T0 and T1 for each vital sign; these are also graphically represented in figure 1. We found significant differences for all measured vital signs. As becomes apparent from figure 1, all vital signs decreased during the measurement time frame, except for peripheral oxygen saturation which increased by 1.1%. The heart rate and respiratory rate dropped by >10% during resuscitation (p9% (p