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It is important to remember that preterm infants continue to develop postnatally and modify the anesthetic to reflect the current physiology of the infant rather than the physiology of the infant at her birth or even a few weeks prior to her procedure. Although these physiologic changes occur Selleckchem PD173074 along a continuum, we will discuss the differences between preterm, term, and ex-premature infants in this article. Preterm infants are generally considered those infants born before 37 postmenstrual weeks until they reach a postmenstrual age of 37?weeks at which time they are considered ex-premature infants. Term infants are those born at or beyond 37 postmenstrual weeks. The distinctions are important because the normative values for blood pressure vary greatly depending on the infant's postmenstrual age. During the first day of life, blood pressure is generally lower than on subsequent days and very close to skirting the accepted definitions of hypotension. For example, normal systolic blood pressure in a term infant during the first day of life is 62.6?mmHg, which is very close to the Pediatric Advanced Life Support definition of neonatal hypotension of a systolic blood pressure of Ulixertinib datasheet week of life, the normal blood pressure for awake term infants is 71.8/50.5�mmHg for girls and 72.7/51.1�mmHg for boys [14]. Preterm infants follow a similar pattern of an increase in blood pressure over the first week of life [15]. In fact, the slope of the increase in blood pressure over the first week of life appears to be the same for all infants regardless of their gestational age. The pooled normative data from over 70?00 children (2526 aged GUCY1B3 showed that the average blood pressure in females from >8�days of life to