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Compared to the TAU, adding DMT seemed to improve the effect of the treatment. There was a tendency for the effect of DMT to be slightly better with patients who were not taking antidepressive medication. Between-group effect sizes between the DMT + TAU and TAU indicated medium or large differences (d = 0.60�C0.85) in the four measures used in this study in favor of the DMT + TAU. In addition, the within-group effect sizes were considerably larger among patients attending to the DMT group. This suggests, that the favorable changes observed when the DMT was added to the TAU may have clinical significance. However, more studies are needed to confirm the clinical effects of DMT. The indication of a statistically significantly greater improvement between the DMT + TAU and TAU groups appeared in the SCL-90 measuring psychiatric symptoms and HADS measuring depression and anxiety symptoms. In these self-evaluation assessments, the verbal content of the statements is geared toward bodily felt sensations, symptoms, and emotions. In the SCL-90 one third of the questions refer to somatization or phenomena that relate to autonomous nervous system arousal. This may be one reason why the change was expressed more clearly through these measurements. In addition to these changes, the DMT group showed favorable changes, although not statistically significant, in symptoms of depression (BDI-II) and global distress (CORE-OM). These observations are in line with the study by Punkanen et al. (2014) using a similar DMT group intervention. In their study the mean decrease on the BDI from baseline to post-measurement was 11.17 points compared to 10.11 points in the present study. Both these studies produced a similar favorable outcome in the treatment of depression. Punkanen et al. (2014) used a 20-session group intervention provided twice a week while the present study applied a 12-session intervention. This suggests that favorable changes could also be achieved using a shorter DMT group intervention. The observations made in this study are also in accordance with the previous reviews by Meekums et al. (2015), Koch et al. (2014), and Papadopoulos and R?hricht (2014). These suggested positive effects of DMT on quality of life and on depression and anxiety. One focus in DMT is engaging with movement activity in the here and now. Further, the aim of activity is to be attentive to the movement Temozolomide in vitro experiences and to develop the skills to be aware of experiences, and to communicate about them in words (Meekums, 2002; Koch and Fischman, 2011; Nolan, 2014). Thus DMT involves experiential exercises including mindfulness skills and attention training. There are several other studies suggesting that this type of training, which includes experiential exercises, could be beneficial to the patients (Hayes et al., 2011; Michalak et al., 2012; Horst et al., 2013; Payne, 2015).