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In the control group the following results were obtained: (1) a slight increase of oxy-Hb before first sensation occurred, (2) there was a continuous increase of oxy-Hb during bladder filling to the point just after voiding began, (3) there was a continuous decrease of oxy-Hb after voiding, (4) in subjects who were unable to urinate, oxy-Hb also decreased after attempting to void, and (5) the area activated was the bilateral lateral prefrontal area, particularly Brodmann's areas 8, 10, and 46. In the detrusor overactivity group, (6) an increase of oxy-Hb before first sensation OTX015 cost was rare and frontal cortical activation was weak, (7) at the moment detrusor overactivity appeared, fNIRS brain activity in the frontal cortex did not change significantly; and otherwise the results were almost the same as those in the control group. This study shows that the frontal micturition area is activated during natural bladder filling and voiding using fNIRS. Neurourol. Urodynam. 29:757�C764, 2010. ? 2010 Wiley-Liss, Inc. ""Determine whether urodynamic measures of urethral function [(valsalva leak point pressure (VLPP), maximum urethral closure pressure (MUCP), functional urethral length (FUL)] and the results of the supine empty bladder stress test (SEBST) correlate with BTK inhibitors high throughput screening each other and with subjective and objective measures of urinary incontinence (UI). Data were collected preoperatively from subjects enrolled in a multicenter surgical trial of mid-urethral slings. Subjective measures included questionnaire scores from the Medical Epidemiological and Social Aspects of Aging Questionnaire, Urogenital Distress Inventory, and Incontinence Impact Questionnaire. Objective measures included a 24-hr pad weight test, incontinence episode frequency on a 3-day voiding diary, and a SEBST. Five hundred ninety-seven women enrolled. Three hundred seventy-two women had valid VLPP values; Transducin 539 had valid MUCP/FUL values. Subjective measures of severity had weak to moderate correlation with each other (r?=?0.25�C0.43) and with objective measures of severity (r?=??0.06 to 0.45). VLPP and MUCP had moderate correlation with each other (r?=?0.36, ?