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This makes NAT1 an see more attractive drug target in cancer therapeutics. Acknowledgments This work was supported by the National Health and Medical Research Foundation of Australia (NHMRC APP1024769). Conflict of Interest None declared.""Lung cancer is still the leading cause of death among women and men in the United States 1. Surgery remains the mainstay treatment option for patients with non�Csmall-cell lung cancer (NSCLC) 2; therefore, a number of perioperative-related factors including tumor stage, margin status, type of resection, and type of anesthetic and analgesic technique have been investigated with the goal of predicting and improving long-term survival 3,4. Neutrophils are key cellular components of the inflammatory system and lymphocytes play Temsirolimus price an important role in immune surveillance and immune editing. Therefore, the neutrophil:lymphocyte ratio (NLR) correlates those two cellular components as a marker of perioperative inflammation 5,6. In the context of cancer, an NLR >5 has been suggested as an independent prognostic factor for decreased recurrence-free survival (RFS) in patients with malignancies, which highlights the importance of perioperative inflammation and immune suppression in oncological outcomes 7�C10. It has been speculated that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during and after surgery could not only modify the tumor microenvironment in which micrometastasis are present but also reduce migration and invasion of circulating malignant cells; therefore, the administration of these drugs in the perioperative period might MRIP have a significant impact on cancer recurrence 11�C13. The perioperative administration of NSAIDs (ketorolac or diclofenac) has been shown to be an independent risk factor for distant metastasis-free survival, and ketorolac administration, specifically, was a predictor of better overall survival (OS) in an observational study of patients with stage I or II NSCLC 8. The aim of this retrospective study was to determine possible associations between preoperative NLR and postoperative use of NSAIDs on RFS and OS in patients with stage I�CIII NSCLC undergoing curative resection. We hypothesized that patients with a low inflammatory status (NLR