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Hypertension was defined as a systolic BP ��140 mm Hg, and/or a diastolic BP ��90 mm Hg, and/or a history of hypertension or taking antihypertensive drugs. Dyslipidemia was defined as a TCHOL ��5.18 mmol/l and/or triglycerides ��1.70 mmol/l and/or HDL-C Sirolimus mouse recruitment and data analyses was obtained from the MJ Research Foundation Review Committee in Taiwan. Cigarette smoking, alcohol consumption, betel nut chewing, and physical activity histories were recorded for each subject from a questionnaire. Current, former, or never users were defined as those subjects who reported current use, any prior use, or never use of betel nuts, respectively, in the baseline survey. Physical activity was divided into 3 levels: none-to-mild (exercise RAD001 research buy 1 to 4 h per week); and vigorous (exercise >5 h per week). Income was divided into 3 levels: low ($37,500/year). Education was also divided into 3 levels: low (elementary school and below); middle (junior and senior high school); and high (college/university and above). All participants (n = 115,746) have complete data for age, sex, BMI, total T4, TSH, BP, fasting glucose, lipid profile, disease status, mortality status, and survival time. Although some lifestyle Biperiden HCl and socioeconomic factors were missing, 83.3% of participants (n = 96,383) had all covariates measured. The data were presented as the mean and standard deviation for continuous variables. The Student t test for unpaired data was used for the comparison of mean values between 2 groups. Proportions and categorical variables were tested by the chi-square test. The characteristics of subjects with SCH or euthyroidism are shown in Table 1. Cox proportional hazards regression analyses adjusted for potential confounders were used to estimate the relative risks (RRs) for death from all causes and from CVD. We adjusted the covariates according to the traditional CVD risk factors or nontraditional risk factors, or on the basis of their relationship with either SCH (predictor) or death (outcome) in univariate analysis (p