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Methods.? This was a randomized, double-blind (observer-blind), single-centre, phase I clinical study with an intraindividual comparison. The topic anti-acne products (nadifloxacin, adapalene, benzoyl peroxide, azelaic acid and isotretinoin) were applied without occlusion, either alone or in combination with nadifloxacin, to the skin test areas. One test area was left untreated. Results.? Most of the mean irritation scores were 0, and all were Resiquimod nadifloxacin with any of the other four topical anti-acne products did not lead to substantial intolerance reactions compared with the effects after application of the products alone. ""UVA radiation is the most prevalent component of solar UV radiation; it deeply penetrates into the skin and induces profound alterations of the dermal connective tissue. In recent years, the detrimental effects of UVA radiation were more precisely demonstrated at cellular and molecular levels, using Compound Library adequate methods to identify biological targets of UVA radiation and the resulting cascade impairment of cell functions and tissue degradation. In particular gene expression studies recently revealed that UVA radiation induces modulation of several genes confirming the high sensitivity of dermal fibroblasts to UVA radiation. The major visible damaging effects of UVA radiation only appear after years of exposure: it has been clearly evidenced that they are responsible for more or less early signs of photoageing and photocarcinogenesis. UVA radiation appears to play a key role in pigmented changes occurring with age, the major sign of skin photoaging in Asians. Skin susceptibility to photoaging alterations also depends on constitutive pigmentation. The skin sensitivity to UV light has been demonstrated selleck products to be linked to skin color type. Solar UV radiation reaching the earth is a combination of UVB (290�C320?nm) and UVA (320�C400?nm) wavelengths. Since UVA radiation is less energetic than UVB radiation, UVB radiation has long been thought to be the factor responsible for the damaging effects of solar radiation. But it is now proved that UVA radiation plays a major role. In fact UVA radiation is the most prevalent component of solar UV radiation, it penetrates deeper than UVB radiation into the skin and induces profound alterations of the dermal connective tissue. In recent years, the detrimental effects of UVA radiation were more precisely demonstrated at cellular and molecular levels, using adequate methods to identify biological targets of UVA radiation and the resulting cascade impairment of cell functions and tissue degradation. UVB radiation reaches the earth in relatively low amounts (about 0.5% of solar spectral irradiance at ground level, integrated over 290�C2500?nm range) and is highly energetic. In contrast, UVA rays are lower in energy, but they are at least 20 times more abundant.