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3 years, 67.7% women). More than half had hypertension (65.1%) and 47.3% had hyperlipidemia (table ?(table1).1). By stage of dementia, 85 patients were at a mild, 90 at a moderate and 11 at a severe stage of dementia. Table 1 Demographic characteristics of the study population (n = 186) Distribution of Allele Genotypes The distribution of PON1 polymorphisms in the study population is presented in table ?table2.2. The genotypes were in Hardy-Weinberg equilibrium and their distribution was not significantly different between the AD patients and the mixed dementia patients (9 QQ, 54 QR, 46 RR; 9 QQ, 39 QR, 29 RR, respectively, p = 0.673). In addition, the presence of at least one R allele (QR or RR) and the presence of Adenine at least one Q allele (QR or QQ) were not significantly different between the AD patients and the mixed dementia patients (91.7 and 88.3%, p = 0.436; 57.8 and 62.3%, p = 0.534, respectively). Likewise, the allele distribution was not significantly different between the two groups: the Q allele frequency was 33.0% in the AD patients and 37.9% in the mixed dementia patients, while the R allele frequency was 67.0% in the AD patients and 63.1% in the mixed dementia patients (p = 0.426). The ratio between Q and R allele frequencies was 0.493 in the AD patients GW3965 solubility dmso and 0.588 in the mixed dementia patients. Table 2 PON1 genotype distribution and allele frequencies in the study population Allele Associations with Cognitive Status, Neuropsychiatric Symptoms and Function In the total group, R allele carriers, compared with non-R allele carriers, showed higher mean NPI-Q (S) scores and NPI-Q (CD) scores (8.80 vs. 4.89, p = 0.004; 8.92 vs. 3.94, p = 0.002, respectively; tables ?tables3,3, ?,4).4). There were no significantly differences in MMSE score (p = 0.426), global CDR score (p = 0.928), Target Selective Inhibitor Library total CDR score (p = 0.407), GDS/FAST score (p = 0.283) and BADLS score (p = 0.303). The same relationships were examined in patients by AD and mixed dementia subtypes. In the mixed dementia group, the presence of the R allele was significantly associated with pronouncedly higher mean NPI-Q (S) scores (9.01 vs. 3.11, p = 0.039) and NPI-Q (CD) scores (9.09 vs. 2.33, p = 0.006), as well as with total CDR scores (8.57 vs. 5.89, p = 0.042), GDS/FAST scores (4.84 vs. 4.11, p = 0.007) and BADLS scores (6.99 vs. 1.00, p