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The ROC curve was done to assess the predictability of these parameters in the diagnosis of Diabetes Mellitus. From ROC curve it was seen that Area under Curves are near to 1, so salivary glucose & PAS Positive buccal mucosal cells can be used as a diagnostic tool in Diabetic Mellitus. Conclusion This study reveals that salivary glucose and PAS positive cells are increased in diabetics which can be considered as adjuvant diagnostic tool for Diabetes Mellitus. Notes Financial or Other Competing Interests None.""Antibiotics are antimicrobials which destroy or slow down the growth of bacteria. The primary function of the antibiotics is to treat the bacterial infection. But unnecessary use of antibiotics would increase the risk of antibiotic resistance. This antibiotic resistance will make the bacteria nonresponsive to the action of given antimicrobial agent and these bacteria will continue their growth and multiplication [1]. Bacterial resistance to antibiotics has become a challenge for clinicians since the discovery of antibiotics because bacteria have succeeded in developing resistance to all antibacterial agents shortly after they had been marketed [2]. In addition to bacterial resistance inappropriate prescription of antibiotics is also associated with several adverse effects on general population [3], ranging from gastrointestinal disturbances to fatal anaphylactic shocks, emergence and dissemination of some species through genetic pathway along with economic misuse [4]. These adverse reactions have drawn the attention of health care professionals, scientists and policy makers towards the problem of antibiotic misuse [3,4]. In dentistry, antibiotics are prescribed for the treatment of odontogenic infections, especially endodontic infections, and prophylaxis of local and systemic spread. The data from different studies showed that 70% of the patients of age 35-44 years have been diagnosed with apical Periodontitis [5]. A survey done in UK, involving more than 6000 GNAT2 dentists showed that 40% of the dentists were prescribing antibiotics at least thrice per week [6]. It has also been shown through research that 15% of the dentists were prescribing the antibiotics daily and such prescription pattern has proved to be unnecessary and inappropriate. Endodontic pain i.e. pain induced by inflammation of dental pulp or periapical tissues alone is not an indication for antimicrobial treatment. The vast majority of infections of endodontic origin could be managed without antibiotics [7,8]. Incorrect use of antibiotics in dentistry may predispose secondary and super infections and render drugs ineffective against potentially fatal medical infectious diseases besides the overhead financial burden on the patients [9].