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Although co-opted vessels were vascular endothelial growth Hesperadin factor-negative, vessels within larger tumor masses were vascular endothelial growth factor-positive. In conclusion, phase contrast MRI is believed to be sensitive to vascular remodeling in co-opting brain tumor metastases independent of sprouting angiogenesis, and may therefore aid in preclinical studies of angiogenic-independent tumors or in the monitoring of continued tumor growth following anti-angiogenic therapy. Published 2011. This article is a US Government work and is in the public domain in the USA. ""Cross-talk between adipose tissue and liver is disturbed in the metabolic syndrome. Moreover, the relative fatty acid composition of adipose and liver fat is poorly characterized. Long-TE 1H MRS can determine the unsaturation and polyunsaturation of adipose tissue. The aim of this study was to use long-TE 1H MRS to determine the composition of liver fat and its relation to adipose tissue composition. Sixteen subjects with increased liver fat (>5%) were recruited for the study. Using TE?=?200?ms, we were able to resolve the olefinic (CH, 5.3?ppm) and water (H2O, 4.7?ppm) resonances in liver spectra and to obtain a repeatable estimate of liver fat unsaturation (coefficient of variation, 2.3%). With TE?=?135?ms, the diallylic (CCH2C, 2.8?ppm) resonance was detectable in subjects with a liver fat content above 15%. Long-TE 1H MRS was also used to determine the unsaturation in subcutaneous find more (n?=?16) and visceral (n?=?11) adipose tissue in the same subjects. Liver fat was more saturated (double bonds per fatty acid chain, 0.812?��?0.022) than subcutaneous (double bonds per fatty acid chain, 0.862?��?0.022, p?AZD2281 correlated with subcutaneous unsaturation (R?=?0.837, p?